Do CAD genetic risk scores predict cardiovascular risk?

CAD genetic risk scores (GRSs) predict risk independently from clinical tools, like QRISK3. We assessed the added value of GRSs for a variety of cardiovascular traits (CV GRSs) for predicting CAD and MACE and tested their early-life screening potential by comparing against the CAD GRS only.

How does CAC score affect the CAD2 clinical model?

The CAD2 clinical model obtained an area under the curve of 0.718 (95% CI, 0.668–0.767). The inclusion of CAC score improved the area under the curve to 0.896 (95% CI, 0.867–0.925) in the CAD2 models and from 0.767 (95% CI, 0.721–0.814) to 0.926 (95% CI, 0.900–0.951) in the local assessment of the heart models.

Does CAC score predict 10-year ASCVD risk?

Furthermore, the CHD-to-stroke incidence ratio across CAC score categories and predicted 10-year ASCVD risk categories (<7.5%, 7.5–20%, and ≥20%) in the overall cohort was also calculated. The risk prediction model used to estimate 10-year ASCVD risk is described later.

What is CAD risk score 1 & 2?

As described in Supplemental Methods, score 1 was QRISK3. Score 2 comprised QRISK3, the CAD GRS, 10 the genetic array, and the fifth and ninth principal components, as they independently contributed to CAD risk ( Table 2 ).